tebu-bio is a European company specialised in providing innovative reagents and laboratory services in Life Sciences
X

Need an answer now?

Give us a call

Leave a message, we'll get back to you





Move

Product added to your basket !


Continue your visit View your basket
50ug EUR 110
110€
100ug EUR 190
190€
500ug EUR 580
580€


Contact us

Recent History

GUANGXITOXIN 1E

Product name
GUANGXITOXIN 1E
Catalog number
11GUA002-00050 (50ug)
11GUA002-00100 (100ug)
11GUA002-00500 (500ug)
Description
GxTx-1E was isolated from the venom of Chilobrachys jingzhao (Chinese earth tiger tarantula). It was shown to block Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels without significant effect on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, Kv3.2/KCNC2, Cav1.2/CACNA1C, Cav2.2/CACNA1B, Nav1.5/SCN5A, Nav1.7/SCN9A or Nav1.8/SCN10A channels. GxTx-1E inhibits Kv2.1 with an IC50 value of 1 nM and Kv2.2 with an IC50 value of 3 nM. Block of Kv4.3 occurs at 10-20 fold higher concentrations. It acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K currents towards depolarized potentials. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
Shipment info
Room Temperature
Nacres Codification
NA.26

Request the Datasheet

First name
Last name
Email *
Country *:
Company name *
  
* Fields marked with an asterisk are required.



Protocol

To access the protocol, please provide your email address :