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100ug EUR 185
185€
500ug EUR 560
560€
1mg EUR 955
955€


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Omega-AGATOXIN IVA

Product name
Omega-AGATOXIN IVA
Catalog number
11AGA001-00100 (100ug)
11AGA001-00500 (500ug)
11AGA001-01000 (1mg)
Description
Omega-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that Omega-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for Omega-agatoxin IVA has been localized in part to the extracellular S3-S4 loop in repeat IV of the Alpha-1A Ca2 channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels. 
Source
Smartox Biotechnology
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
CAS number
145017-83-0
Shipment info
Room Temperature
Nacres Codification
NA.26

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