Omega-AGATOXIN IVA

• Specifications
• Datasheet
• Tech Info

Product name

Omega-AGATOXIN IVA

Catalog number

11AGA001-00100 (100ug)
11AGA001-00500 (500ug)
11AGA001-01000 (1mg)

Description

Omega-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that Omega-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for Omega-agatoxin IVA has been localized in part to the extracellular S3-S4 loop in repeat IV of the Alpha-1A Ca2 channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels. 

Source

Smartox Biotechnology

Product category

Proteins & Peptides

Product sub category

Peptides

Label

No

CAS number

145017-83-0

Shipment info

Room Temperature

Nacres Codification

NA.26