Omega-AGATOXIN IVA
- Product name
- Omega-AGATOXIN IVA
- Catalog number
- 11AGA001-00100 (100ug)
11AGA001-00500 (500ug)
11AGA001-01000 (1mg) - Description
-
Omega-agatoxin IVA is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that Omega-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for Omega-agatoxin IVA has been localized in part to the extracellular S3-S4 loop in repeat IV of the Alpha-1A Ca2 channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
- Source
- Smartox Biotechnology
- Product category
- Proteins & Peptides
- Product sub category
- Peptides
- Label
- No
- CAS number
- 145017-83-0
- Shipment info
- Room Temperature
- Nacres Codification
- NA.26