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100ug EUR 165
165€
500ug EUR 440
440€
1mg EUR 660
660€


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APETx2

Product name
APETx2
Catalog number
07APE002-00100 (100ug)
07APE002-00500 (500ug)
07APE002-01000 (1mg)
Description
APETx2 is a toxin that was originally isolated from Anthopleura elegantissima (Sea anemone). APETx2 selectively Chagot, B et al. (2005) Protein Sci 14, 2003-2010. blocks the H()-gated sodium channel ASIC3 (ACCN3). The blockage is rapid and reversible. This toxin does not block isoform ASIC1a and isoform ASIC1b of ASIC1 (ACCN2), nor ASIC2 (ACCN1). It also inhibits the heteromeric ASIC2b-ASIC3 channelIt has less affinity for ASIC1b-ASIC3, ASIC1a-ASIC3, and no effect on the ASIC2a-ASIC3 channels. IC50 is 63 nM on ASIC3 channel. IC50 is 117 nM on ASIC2b-ASIC3 heteromeric channel. IC50 is 0.9 MuM on ASIC1b-ASIC3 heteromeric channel. IC50 is 2 MuMon ASIC1a-ASIC3 heteromeric channel. 
Product category
Proteins & Peptides
Product sub category
Peptides
Label
No
Shipment info
Room Temperature
Source
Smartox Biotechnology

Protocol

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