PUROTOXIN 1

• Specifications
• Datasheet
• Tech Info

Product name

PUROTOXIN 1

Catalog number

011PUR001-00100 (100ug)
011PUR001-00500 (500ug)
011PUR001-01000 (1mg)

Description

Purotoxin1 (PT-1) is a peptide originally isolated from the Central Asian spider Geolycosa sp. It was shown to inhibit selectively P2X3 receptor channels at a 100 nM concentration. Studies were carried-out on cultured rat DRG neurons. Patch-clamp experiments did not show any inhibitory effect of PT-1 on voltage-gated channels (potentials range tested from -100 to 20 mV), neither on TRPV1 (after activation with 500 nM capsaicin). The selectivity of PT-1 for P2X3 was highlighted by activating this receptor with 10 uM ATP and 100 uM Alpha, Beta Methylene-ATP. Indeed, unlike P2X3, P2X2 and heterodimer P2X2/3 are known to be not sensitive to such concentrations. Moreover, P2X3, P2X2, and P2X2/3 are the only known ATP-sensitive receptors expressed in plasma membranes of DRG neurons. So, the observed effect seems to be well related to a selective inhibition of P2X3. P2X3-mediated current was fully inhibited with 100 nM PT-1, making it the most potent and selective ligand for P2X3. 

Source

Smartox Biotechnology

Product category

Proteins & Peptides

Product sub category

Peptides

Label

No

Shipment info

Room Temperature

Nacres Codification

NA.26