P22077, inhibitor

• Specifications
• Datasheet

Product name

P22077, inhibitor

Catalog number

SI9699-10MG (10mg)
SI9699-50MG (50mg)

Description

P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7(IC50=8.6MuM), and the closely related deubiquitinase (DUB) USP47. P22077showed weak or no inhibition (EC50>50MuM) towards a panel of 14isopeptidases and other proteases. Treatment of cells with P22077 (20-40MuM)causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin. 

Source

LifeSensors

Product category

Molecules

Product sub category

Inhibitors & Activators

Application

Other

Pathway

Ubiquitination

CAS number

1247819-59-5

Shipment info

Dry Ice

Nacres Codification

NA.28