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10mg EUR 158
158€
50mg EUR 561
561€


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P22077, inhibitor

Product name
P22077, inhibitor
Catalog number
SI9699-10MG (10mg)
SI9699-50MG (50mg)
Description
P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7(IC50=8.6MuM), and the closely related deubiquitinase (DUB) USP47. P22077showed weak or no inhibition (EC50>50MuM) towards a panel of 14isopeptidases and other proteases. Treatment of cells with P22077 (20-40MuM)causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin. 
Source
LifeSensors
Product category
Molecules
Product sub category
Inhibitors & Activators
Application
Other
Pathway
Ubiquitination
CAS number
1247819-59-5
Shipment info
Dry Ice
Nacres Codification
NA.28

Protocol

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