P22077, inhibitor
- Product name
- P22077, inhibitor
- Catalog number
- SI9699-10MG (10mg)
SI9699-50MG (50mg) - Description
-
P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7(IC50=8.6MuM), and the closely related deubiquitinase (DUB) USP47. P22077showed weak or no inhibition (EC50>50MuM) towards a panel of 14isopeptidases and other proteases. Treatment of cells with P22077 (20-40MuM)causes an accumulation of K48-linked ubiquitinated species, and downregulation of the USP7 targets HDM2 and claspin.
- Source
- LifeSensors
- Product category
- Molecules
- Product sub category
- Inhibitors & Activators
- Application
- Other
- Pathway
- Ubiquitination
- CAS number
- 1247819-59-5
- Shipment info
- Dry Ice
- Nacres Codification
- NA.28