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5mg EUR 152
152€
25mg EUR 530
530€


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NIGERICIN

Product name
NIGERICIN
Catalog number
BIA-N1228-1 (5mg)
BIA-N1228-2 (25mg)
Description
Purity > 98%-Nigericin is a polyether antibiotic produced by Streptomyces isolated in the 1950s, notably S. hygroscopicus. Its complex structure was finally elucidated in 1968. Nigericin is an ionophore, possessing a very high affinity for monovalent cations such as Na and K. Nigericin disrupts membrane potential and Golgi apparatus in mitochondria. Although nigericin can be isolated as the free acid (under acidic conditions), like most ionophores it is extracted into organic solvents and is most conveniently isolated as a salt. In vitro, nigericin has a broad biological profile activity against Gram positive bacteria, fungi, tumor cell lines and some viruses, including HIV. Nigericin is the most common member of the polyether class which are common false positives in in vitro screening bioassays using crude microbial extracts. They are thus important standards for dereplication. -Alternative names: -Polyetherin A, Azalomycin M, Helixin C, Antiotic K 178, Antibiotic X 464, Pandavir 
Source
BioAustralis Fine Chemicals
Product category
Molecules
Product sub category
Antibiotics & Metabolites
CAS number
28380-24-7
Shipment info
Room Temperature
Nacres Codification
NA.28

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