Gliotoxin

• Specifications
• Datasheet

Product name

Gliotoxin

Catalog number

BIA-G1260-1 (1mg)
BIA-G1260-2 (5mg)

Description

Purity > 99%-Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species in the genera Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin has been shown to inhibit a broad range of unrelated mechanisms, such as inhibition of chymotrypsin-like activity of the 20S proteasome, Ca2 release from mitochondria, activation of transcription factor NF-KappaB in response to a variety of stimuli in T and B cells, anti-inflammatory activity and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction to proteins through mixed disulphide formation. gliotoxin has been shown to inhibit a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity. 

Source

BioAustralis Fine Chemicals

Product category

Molecules

Product sub category

Antibiotics & Metabolites

CAS number

67-99-2

Shipment info

Room Temperature

Nacres Codification

NA.28

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