Gliotoxin
- Product name
- Gliotoxin
- Catalog number
- BIA-G1260-1 (1mg)
BIA-G1260-2 (5mg) - Description
-
Purity > 99%-Gliotoxin is a potent epithiodioxopiperazine mycotoxin produced by species in the genera Gliocladium, Aspergillus and Penicillium. At the cellular level gliotoxin has been shown to inhibit a broad range of unrelated mechanisms, such as inhibition of chymotrypsin-like activity of the 20S proteasome, Ca2 release from mitochondria, activation of transcription factor NF-KappaB in response to a variety of stimuli in T and B cells, anti-inflammatory activity and inhibition of farnesyltransferase and geranylgeranyltransferase. The mode of action appears to be via covalent interaction to proteins through mixed disulphide formation. gliotoxin has been shown to inhibit a number of thiol-requiring enzymes and also displays antioxidant and immunomodulatory activity.
- Source
- BioAustralis Fine Chemicals
- Product category
- Molecules
- Product sub category
- Antibiotics & Metabolites
- CAS number
- 67-99-2
- Shipment info
- Room Temperature
- Nacres Codification
- NA.28