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2 vials EUR 10874
10874€


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Adenosine A2A Receptor Functional Recombinant Cell Line

Product name
Adenosine A2A Receptor Functional Recombinant Cell Line
Catalog number
79381 (2 vials)
Description
Adenosine A2a receptor (A2aR or ADORA2A) stably expressed in HEK-293 reporter cells with a cAMP-responsive luciferase construct (CRE/CREB Luc, BPS Bioscience, #60515). A2aR is a member of the seven transmembrane G protein-coupled receptor (GPCR) family. The activity of A2aR is mediated by Gs protein which activates adenylyl cyclase, resulting in the synthesis of intracellular cAMP. The level of cAMP correlates with the respective adenosine (agonist) level, and the cell line can be used to measure the EC50 and IC50 values of A2aR agonists or antagonists in a quantitative manner. Binding of extracellular adenosine ligand or its stable analog NECA (5'-(N-Ethylcarboxamido) adenosine) to the A2aR expressed on the surface of this cell line can also produce luciferase reporter signal for qualitative measurement. 
Source
BPS Bioscience
Product category
Cells, Media & Fractions
Product sub category
Cell Lines
Biological activity
 
Shipment info
Dry Ice
Nacres Codification
NA.81

Protocol

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