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96 rxns EUR 693
693€

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B-Raf(V600E) Kinase Assay Kit

Product name
B-Raf(V600E) Kinase Assay Kit
Catalog number
48688 (96 rxns)
Description
B-raf, after stimulation by activated RAS, phosphorylates MEK1 resulting in activation of the mitogen-activated protein (MAP) kinase cascade. Since the MAPK cascade has been shown to be a critical factor in melanoma development, it has been proposed that targeting B-raf could be a promising approach to combat melanoma. More importantly, 40-60% of melanomas display a mutation in BRAF, e.g. B-Raf(V600E), which leads to constitutive activation of the MAP kinase pathway. The B-Raf(V600E) Kinase Assay Kit is designed to measure B-Raf(V600E) kinase activity for screening and profiling applications using Kinase-Glo MAX as a detection reagent. In addition, the B-Raf(V600E) Kinase Assay Kit includes wild type B-Raf enzyme as a positive control for researchers investigating B-Raf(V600E) specific inhibitors.
Synonyms: BRAF1, RAFB1, B-raf 1, MGC126806, MGC138284, BRAF (V600E) 
Source
BPS Bioscience
Product category
Assays & Kits
Product sub category
Functional Assays
Biological activity
 
Shipment info
Dry Ice
Nacres Codification
NA.84

Protocol

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