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10 mg EUR 509
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Recent History

AT13387

Product name
AT13387
Catalog number
27736-2 (10 mg)
Description
AT13387, discovered by a high-throughput x-ray craystallography fragment-based platform, is a non-geldanamycin inhibitor of heat shock proterin 90 (HPS90), a molecule chaperone regulating signal transduction pathways for cell growth and survival. It has high affinity for binding HSP90 (Kd = 0.5nM) and exhibited an in vitro cytotoxicity showing a median EC50 value of 41 nM. The antitumor activity of AT13387 against solid tumor and leukemia models is similar to alvespimycin.
Synonyms: (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone 
Source
BPS Bioscience
Product category
Molecules
Product sub category
Inhibitors & Activators
Target's name
HSP90
Biological activity
 
Shipment info
Cool Pack
Nacres Codification
NA.28

Protocol

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