AT13387

• Specifications
• Datasheet

Product name

AT13387

Catalog number

27736-2 (10 mg)

Description

AT13387, discovered by a high-throughput x-ray craystallography fragment-based platform, is a non-geldanamycin inhibitor of heat shock proterin 90 (HPS90), a molecule chaperone regulating signal transduction pathways for cell growth and survival. It has high affinity for binding HSP90 (Kd = 0.5nM) and exhibited an in vitro cytotoxicity showing a median EC50 value of 41 nM. The antitumor activity of AT13387 against solid tumor and leukemia models is similar to alvespimycin.
Synonyms: (2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone 

Source

BPS Bioscience

Product category

Molecules

Product sub category

Inhibitors & Activators

Target's name

HSP90

Biological activity

 

Shipment info

Cool Pack

Nacres Codification

NA.28