1,10-Phenanthroline, Monohydrate

• Specifications
• Datasheet

Product name

1,10-Phenanthroline, Monohydrate

Catalog number

27713 (0.5 ml)

Description

1,10-phenanthroline (o-phenanthroline) is a chelator with high affinity for divalent metal ions. When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions. While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn²⁺ ion. As such, o-phenanthroline is widely used when preparing cell lysates for enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.
Synonyms: o-phenanthroline 

Source

BPS Bioscience

Product category

Molecules

Product sub category

Inhibitors & Activators

Application

Useful for inhibition of JAMM-family isopeptidases. Especially valuable for protecting K63-linked polyubiquitin chains in cell lysates.

Format

DMSO solution

Biological activity

 

Shipment info

Room Temperature

Nacres Codification

NA.28