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0.5 ml EUR 407
407€


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1,10-Phenanthroline, Monohydrate

Product name
1,10-Phenanthroline, Monohydrate
Catalog number
27713 (0.5 ml)
Description
1,10-phenanthroline (o-phenanthroline) is a chelator with high affinity for divalent metal ions. When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions. While not specific for DUBs, it has been shown to be a potent inhibitor of JAMM-type isopeptidases through chelation of the active site Zn2+ ion. As such, o-phenanthroline is widely used when preparing cell lysates for enrichment of proteins bearing K63-linked polyubiquitin chains which are especially sensitive to DUBs in the JAMM family.
Synonyms: o-phenanthroline 
Source
BPS Bioscience
Product category
Molecules
Product sub category
Inhibitors & Activators
Application
Useful for inhibition of JAMM-family isopeptidases. Especially valuable for protecting K63-linked polyubiquitin chains in cell lysates.
Format
DMSO solution
Biological activity
 
Shipment info
Room Temperature
Nacres Codification
NA.28

Protocol

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