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5 mg EUR 380
380€
10 mg EUR 666
666€


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AG-14361

Product name
AG-14361
Catalog number
27602-1 (5 mg)
27602-2 (10 mg)
Description
AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks.
Synonyms: 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one 
Source
BPS Bioscience
Product category
Molecules
Product sub category
Inhibitors & Activators
Target's name
PARP1
Biological activity
 
Shipment info
Cool Pack
Nacres Codification
NA.28

Protocol

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