AG-14361

• Specifications
• Datasheet

Product name

AG-14361

Catalog number

27602-1 (5 mg)
27602-2 (10 mg)

Description

AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. AG14361 treatment before irradiation statistically significantly increases the sensitivity to radiation therapy. AG14361 enhances the growth-inhibitory and cytotoxic effects of topoisomerase I poisons and increases the persistence of camptothecin-induced DNA single-strand breaks.
Synonyms: 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one 

Source

BPS Bioscience

Product category

Molecules

Product sub category

Inhibitors & Activators

Target's name

PARP1

Biological activity

 

Shipment info

Cool Pack

Nacres Codification

NA.28