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10mg EUR 333
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NLG919, inhibitor

Product name
NLG919, inhibitor
Catalog number
27337-1 (10mg)
Description
NLG919 is an orally available potent inhibitor of the indoleamine-2,3-dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediatesimmunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated forthe treatment of immunosuppression associated with cancer. 
Source
BPS Bioscience
Product category
Molecules
Product sub category
Inhibitors & Activators
Application
Other
Pathway
PI3K/Akt/mTOR Signaling
CAS number
1402836-58-1
Shipment info
Dry Ice
Nacres Codification
NA.28

Protocol

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