NLG919, inhibitor

• Specifications
• Datasheet

Product name

NLG919, inhibitor

Catalog number

27337-1 (10mg)

Description

NLG919 is an orally available potent inhibitor of the indoleamine-2,3-dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediatesimmunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated forthe treatment of immunosuppression associated with cancer. 

Source

BPS Bioscience

Product category

Molecules

Product sub category

Inhibitors & Activators

Application

Other

Pathway

PI3K/Akt/mTOR Signaling

CAS number

1402836-58-1

Shipment info

Dry Ice

Nacres Codification

NA.28