NLG919, inhibitor
- Product name
- NLG919, inhibitor
- Catalog number
- 27337-1 (10mg)
- Description
-
NLG919 is an orally available potent inhibitor of the indoleamine-2,3-dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediatesimmunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated forthe treatment of immunosuppression associated with cancer.
- Source
- BPS Bioscience
- Product category
- Molecules
- Product sub category
- Inhibitors & Activators
- Application
- Other
- Pathway
- PI3K/Akt/mTOR Signaling
- CAS number
- 1402836-58-1
- Shipment info
- Dry Ice
- Nacres Codification
- NA.28