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5mg EUR 252
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Cediranib

Product name
Cediranib
Catalog number
27036 (5mg)
Description
Cediranib, also known as AZD2171, is a highly potent inhibitor of recombinant KDR tyrosine kinase activity in vitro (IC50 < 1 nM). Inhibitory activity was also observed against the kinase associated with Flt-1 (IC50 = 5 nM), the VEGF-C and VEGF-D receptor Flt-4 (IC50 = 3 nM), recombinant PDGFR-related kinase c-Kit (IC50 = 2 nM), and PDGFRß tyrosine kinase (IC50 = 5 nM). In HUVEC, it inhibited VEGF-stimulated phosphorylation of KDR, c-Kit, PDGFR-a , PDGFR-ß in a dose-dependent manner with IC50 values of 0.5, 1, 5, and 8 nM, respectively. Cediranib exhibits antitumor and antiangiogenic activity, and is a potential treatment for hypertension. 
Source
BPS Bioscience
Product category
Molecules
Product sub category
Inhibitors & Activators
Application
Other
Pathway
Tyrosine Kinase/Adaptors
CAS number
288383-20-0
Shipment info
Dry Ice
Nacres Codification
NA.28

Protocol

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