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1ml EUR 2212

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451lLu BR Viable Cells (5 x 10^6 cells)

Product name
451lLu BR Viable Cells (5 x 10^6 cells)
Catalog number
451lLu BR-01-0005-A (1ml)
Background : 451ILu BR is a human metastatic melanoma cell line. This cell line is resistant to BRAF and MEK inhibitors. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. This cell line was derived from the same patient as the cell lines, WM164, and 451Lu. 451ILu BR cells produce xenograft tumors when injected into immunocompromised mice.
Application Note : The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways. 
Product category
Cells, Media & Fractions
Product sub category
Cell Lines
Target species
Shipment info
Dry Ice
Nacres Codification

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