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200ul EUR 538
538€


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Anti NOTCH 1 Human

Product name
Anti NOTCH 1 Human
Catalog number
100-401-407 (200ul)
Description
Anti-Human NOTCH 1 (Cleaved N Terminal) Antibody - Western Blot tebu-bio Background : Anti-Notch 1 Antibody recognizes Notch 1 that is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
Application Note : Anti-Notch 1 is reactive with Notch 1 by western blotting, Immunohistochemistry (IHC) and ELISA.    An 80 kDa band corresponding to Notch 1 was observed at a 1:500 dilution.  Specific conditions for reactivity should be optimized by the end user. 
Source
Rockland
Product category
Antibodies
Product sub category
Primary Antibodies
Target species
Human
Cross-reactivity
Mouse, Human, Rat
Host
Rabbit
Application
ELISA, WB, IP
Label
No
Biological activity
nd
Shipment info
Dry Ice
Nacres Codification
NA.41

Protocol

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Anti-Human NOTCH 1 (Cleaved N Terminal) Antibody - Western Blot tebu-bio