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Stem Cells - Small Molecules

We have selected small molecules for you, which are involved in cellular reprogramming, maintenance and differentiation of stem cells. 

Click on the blue boxes to select your molecule.

BMP, TGFb, Notch, Smoothend & Cadherin pathways

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FGF & Wnt pathways

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Epigenetic pathways

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Other molecules

Molecule Description
PS48 Stemolecule PS48 is an allosteric small molecule that activates phosphoinositide-dependent protein kinase 1 (PDK1) by binding exclusively to the HM/PIF binding pocket rather than the ATP-binding site
A769662 Stemolecule A769662 is a cell-permeable small molecule that activates AMP-activated protein kinase (AMPK).
All-Trans Retinoic Acid Stemolecule All-Trans Retinoic Acid is the oxidized form of Vitamin A and functions as a signaling molecule for various developmental pathways that control differentiation and proliferation. It acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), which then bind to RAREs in the regulatory regions activating gene transcription
BI-D1870 Stemolecule BI-D1870 is a highly specific small molecule inhibitor of Ribosomal S6 Kinase (RSK1, RSK2, RSK3 and RSK4 isoforms), which acts as an ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK.
Pifithrin-Mu Stemolecule Pifithrin-u inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL.
Pyrintegrin Stemolecule Pyrintegrin is a selective, cell permeable small molecule that was identified to enhance the survival of human embryonic stem cells (hESCs).
SMO antagonist Stemolecule SMO Antagonist is an analog of SANT-21.