SUPPLYING DISCOVERY TOOLS

APRIL 2016

NEWS HIGHLIGHT

Transitioning iPSC to Naive Human stem cells

Induced-pluripotent stem cells are produced from a variety of source tissues. For Human iPSC, the pluripotency state is sometimes referred to as the “primed” state. Among iPSC lines, heterogeneity has been shown to exist in proliferation and the capacity to differentiate. This can cause issues in data interpretation or even limit the utility of Human iPSC in some disease cell models for basic research or drug discovery. Recent publications have shown that Human iPSC, when cultured under special conditions, can be transitioned to what may be a more primitive form perhaps similar to cells in the pre-implantation state of a developing embryo.

See how reproNaïve medium can help you to generate & maintain naive cells

Toxicity Assessment of Co-Culture Human Systems

Many chemotherapeutic drugs require bioactivation before they reach full potency. 

This bioactivation is accomplished through many different mechanisms but frequently in the liver before the drug enters circulation. The inadequacy of animal models to predict human biology in the drug development process is becoming increasingly clear due to species differences in uptake and metabolism at both the cellular and organ levels.

The feasibility of creating a multi-organ system capable of testing the ability of a human liver cell line to activate a panel of chemotherapeutic drugs has recently been demonstrated.

Download the poster presented at SOT2016 about this technology

PRODUCT FOCUS

CBR-5884 – a Serine biosynthesis inhibitor for cancer research

Recently, some researchers have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma. Many types of cancer require synthesis of serine to sustain their rapid growth. To find a drug candidate that interfered with this pathway, scientists screened a large library of compounds searching for molecules that inhibited a specific enzyme known as 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first step in cellular serine biosynthesis.

CBR-5884 is now available for your research

Tubulin: Microtubule ratio measured in cells

How can you measure changes of the ratio between free tubulin and filamentous microtubules in cells? The method described here is based on the most reproducible and accurate method of determining the amount of microtubule content versus free-tubulin content in a cell population.

Discover the Microtubules/Tubulin in ViVo Assay Kit

QuickExtract™ DNA Extraction Solution

QuickExtract™ DNA Extraction Solution (Epibio - Illumina) enables rapid and efficient PCR-ready genomic DNA extraction from almost any sample type (eg. hair follicles, tissue-culture cells, buccal cells, zebrafish organs, mouse tail snips...).

  • Fast one-tube protocol (3-8 minutes depending on sample type)
  • Efficient with no use of any toxic organic reagents or spin columns
  • Inexpensive and scalable processing compatible with robotic automation
Get your PCR-ready genomic DNA samples in less than 8 minutes

PROMOTION

Choose 2 tubulin items and get 15% discount

  • Polymerization Assays
  • Binding Assays
  • Pre-formed Microtubules
  • Pure, active Proteins

Valid up to April 30th 2016 - Please mention CA0361-037 on your order to benefit from this discount.

Get your PCR-ready genomic DNA samples in less than 8 minutes

Save 25% off Rockland Cancer Research Antibodies

To celebrate this years annual meeting of the American Association for Cancer Research in New Orleans (AACR 2016), tebu-bio is offering 25% discount off all Rockland Immunochemicals' Cancer Research antibodies up to May 15, 2016. 

Please mention CANCERAB-AACR16 on your web order to benefit from this discount.

How to get your 25% Discount

NEWS

sIFNAR2 antibody used to develop a new ELISA for MS

A recent publication presents the development of a new sandwich ELISA method to check sIFNAR2 levels in Multiple Sclerosis patients... [ Read more ]

Extraordinary” CAR T Cells eliminate cancer after stem cell transplant

CAR T cells continue to make waves: At the latest annual meeting of the American Association for the Advancement of Science, it was announced that CAR T cells, in which T cells from a patient are genetically reprogrammed to target cancer cells, removed all traces of cancer in the bone marrow of 27 out of 29 acute lymphoblastic leukemia patients. Nineteen of 30 individuals with non-Hodgkin lymphoma also responded in the form of partial or complete responses. The cumulative successes found in CAR T cell studies have labeled them “extraordinary.”...[ Read more ]

TECHNICAL CORNER

Oxidative stress is based on the imbalance between the production of free radicals and the ability of the body to detoxify their hazardous effects through neutralization by antioxidants. Free radicals and reactive oxygen species (ROS) are highly reactive molecules that are generated by normal cellular processes, environmental stress, and UV irradiation. Organisms have developed complex antioxidant systems to protect themselves from oxidative stress, however, excess ROS can overwhelm the systems and cause severe damage.

2 versatile methods to measure the anti-oxidative potential of your sample

MEET US

tebu-bio's experts will be at AACR Annual Meeting 2016 in New Orleans, United States from April 16th to 20th.

 

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