Cell Sourcing & Cell Culture Innovation

April 2016

PRODUCT FOCUS

Cell signaling isn'’t static...… your cell culture shouldn’'t be either

Complex cell culture systems are emerging as key tools to improve physiological relevance of in vitro assay systems. There have been two main ways by which investigators attempt to improve mimicking of physiological conditions in cell and tissue culture: co-cultured in a 3D structure or incorporation of fluidic-flow. Despite the success of better recapitulating function at the cellular level using these two methods, neither of these approaches addresses the issue of the non-linear nature of the drug or toxicant exposure as is observed in an in vivo system.

So what's new in this area? We were interested to discover the following system, which we think will also be of interest to many researchers.

Take a closer look at the characteristics and how it can be used.

Melanoma cell lines: Bridge the gap between patient and lab samples

Rockland Immunochemicals Inc. has partnered with the Wistar Research Institute, to produce, validate and distribute a diverse panel of low passage melanoma cell lines from freshly excised metastases. More than 100 melanoma cell lines are grouped for BRAF, N-RAS, KIT, PTEN and CDK4 mutations. These pre-clinical tumour cell lines models can be used to identify the critical target genes and pathways enacted by genomic alterations and lead to more accurately prediction of the effectiveness of novel cancer therapeutics and facilitate cancer research.

Discover all Melanoma Cell Lines available for your research

NEWS

Why is the hCMEC/D3 cell line a robust in vitro BBB model?

The Blood-Brain Barrier (BBB) affects the development of drugs for all pathologies (brain exposure to drugs, side effects...). In the early phases of drug development, there is a strong need for stable and fully characterized human brain endothelial cellular models that might mimic the molecular and cellular interactions between the blood and the brain in vitro.

Let's take a look at a brain endothelial cell line with proven applications in drug discovery: the hCMEC/D3 Human Cerebral Microvascular Endothelial Cell Line...
[ Read more ]

“Extraordinary” CAR T Cells Eliminate Cancer After Stem Cell Transplant

CAR T cells continue to make waves: At the latest annual meeting of the American Association for the Advancement of Science, it was announced that CAR T cells, in which T cells from a patient are genetically reprogrammed to target cancer cells, removed all traces of cancer in the bone marrow of 27 out of 29 acute lymphoblastic leukemia patients. Nineteen of 30 individuals with non-Hodgkin lymphoma also responded in the form of partial or complete responses. The cumulative successes found in CAR T cell studies have labeled them “extraordinary.”... [ Read more... ]

TECHNICAL CORNER

Cell encapsidation and bio-printing are promising experimental approaches for miniaturized 3D-cell cultures. These cell-based assays cover a wide range of applications (e.g. Drug discovery purposes, tissue engineering...).
But which biomaterial can one use to obtain reliable functional cell-based assays? How can you get biologically relevant data? Which critical properties should the biomaterial have for optimal bioprinting?

Essential for cell bio-printing: fully control your hydrogel

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