Stem Cell Biology

March 2016

NEWS HIGHLIGHT

Transitioning iPSC to Naive Human stem cells

Induced-pluripotent stem cells are produced from a variety of source tissues. For Human iPSC, the pluripotency state is sometimes referred to as the “primed” state. Among iPSC lines, heterogeneity has been shown to exist in proliferation and the capacity to differentiate. This can cause issues in data interpretation or even limit the utility of Human iPSC in some disease cell models for basic research or drug discovery. 

Recent publications have shown that Human iPSC, when cultured under special conditions, can be transitioned to what may be a more primitive form perhaps similar to cells in the pre-implantation state of a developing embryo. 

See how reproNaïve medium can help you to generate & maintain naive cells

Find your stem cell Antibody Array

For some years now, antibody arrays have been available to study markers in various areas like Immunology, Atherosclerosis, Inflammation, Angiogenesis, Immunoediting and even signaling pathways. So far, however, and in spite of the growing demand by researchers working on stem cells, there were no antibody arrays for this area of research, meaning that individual Western Blots had to be performed. A new antibody array is now available for the simultaneous detection and analysis of the relative protein expression levels of 15 stem cell markers.

5 reasons to use an Antibody array for your stem cell research

PRODUCT FOCUS

Biomarkers of stemness

Stem Cells are used more and more often in biomedical research, not only for regenerative medicine but also for the study of genetic diseases and development of new treatments. One of the first things to do when you’re working on this kind of cells is to check their stemness. 
In this post, Elodie invites you to look at a popular antibody allowing you to monitor the level of differentiation of your cellular model, as well as an innovation related to antibody arrays and stem cell research...

Discover 2 tools for your stem cells research

Improving restorative surgery — with Platelets

Lipotransfers are ideal for restorative surgery, but retention is a problem. In a recent study, PRP grade concentrated platelets were used for a study examining how platelet-rich plasma helps to enhance fat graft survival. In this post, our specialist explains why PRP grade concentrated platelets were key to illuminating the ways in which platelet-rich plasma enhances fat graft survival.

Use HemaCare’s platelets for your research

NEWS

New way for derivation & maintenance of naive Human PSCs

Newly added to the Stemolecule portfolio are three small molecules which support a new approach for the derivation and maintenance of naïve human pluripotent stem cells. These three newly identified small molecules,WH-4-023, SB590885 and IM-12, are all kinase inhibitors... [ Read more ]

TECHNICAL CORNER

The CRISPR-CAS9 system may well have opened Pandora’s box, but it is also definitely the cornucopia of genome editing. We can do what we want in the genome: settle a mutation, correct a mutation, insert a fluorescent tag to a protein, add an exogenous gene, delete an endogenous function, suppress a cis-regulatory region, add a reporter…...

The main challenge is to define a good strategy, taking in account the specifics of the project and being aware of the corresponding limitations. In this overview, our expert Dimitri focuses on the biotechnology and the concerns of the end-users from a practical point of view.

Download your Guide to choosing the best strategies for CRIPSR-Cas9

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