Gene Expression &
Molecular Biology

March 2016

NEWS

Develop your cell-based assay with real-time GLuc detection

Gaussia Luciferase (GLuc) is a widely accepted gene reporter system used in cell-based assays for various applications. Usually, each new Luciferase reporter assay developed required numerous preliminary assays to test various experimental conditions... but this is set to become a thing of the past.

Recently, a modified version (mGLuc) has become available to obtain even more stable and sensitive readout. Now, the assay development of Luciferase reporter assays is no longer challenging and tedious.

Save time & accuracy with GLuc-ON™ reporter systems

mScript: your 4-in-1 mRNA production system

Since about 5 years now, there has been a renewed interest for mRNA molecules and their numerous applications. Mature mRNAs can be transfected into cells for various purposes without the need for cloning strategies in expression vectors. In addition, mRNA molecules are now becoming a promising elements in Drug Discovery to deliver genetic information and mRNA-based therapeutics in cells.

Whatever the application used, mRNA production by in vitro transcription is tricky and deserves high quality enzymes...

Take a look at the mScript technology for optimized mRNA productions

PRODUCT FOCUS

Which are the best CRISPR-CAS9 strategies?

The CRISPR-CAS9 system may well have opened Pandora’s box, but it is also definitely the cornucopia of genome editing. We can do what we want in the genome: settle a mutation, correct a mutation, insert a fluorescent tag to a protein, add an exogenous gene, delete an endogenous function, suppress a cis-regulatory region, add a reporter…

The main challenge is to define a good strategy, taking in account the specifics of the project and being aware of the corresponding limitations. In this overview, our expert Dimitri focuses on the biotechnology and the concerns of the end-users from a practical point of view.

Download your Guide to choosing the best strategies for CRIPSR-Cas9

Your PCR-ready DNA samples in only 3-10 minutes

The QuickExtract™ DNA Extraction Solution can be used to rapidly and efficiently extract PCR-ready genomic DNA from almost any sample type using a simple, one-tube protocol that takes only 3-8 minutes, depending on the sample. QuickExtract Solution has been used to extract DNA from samples such as hair follicles, quill-end cells of feathers, tissue-culture cells, buccal cells, zebrafish organs and scales, and mouse tail snips. The extracted DNA is suitable for PCR analysis, such as genomic, transgenic, or viral DNA screening in animals, or for genetic or environmental research and screening in humans and other organisms.

Quickly and easily prepare your RNA for RT-PCR

Why you should outsource your plasmid preps

Plasmid preps are to science what salt is to cooking. It’s so common that nobody notices, but nothing can be done without them. There is no mention of this step in any published paper, nobody refers to it in any activity reports, no comments are made on time spent on it... 

But time management in labs is a crucial factor to keep ahead in a competitive world. Results are needed rapidly in order to publish, submit to congresses, request grants & funds... So who, now, can openly say that plasmid preps are not a waste of time? It all becomes a matter of optimization.

Get your purified plasmid in just 14 days

TECHNICAL CORNER

Looking for an efficient miRNA profiling approach?

miRNA are involved in numerous physiological and diseased biological mechanisms. They are now candidates for potent biomarkers in some cancers. The full miRnome contains about 2 000 Human miRNA, and current miRNA profiling methods require improvement in terms of sensitivity and robustness, mainly for low abundance miRNAs. 

Accessing miRNA profiling tools is crucial for both researchers and clinicians. Just send us your samples and receive user-friendly experimental data ideal for your biomarker discovery programs.

Use our 3D-gene® miRNA and mRNA expression profiling service

Why will mixed mode resins revolutionise R&D scale mAb production?

Monoclonal antibody (mAb) engineering and their development as therapeutic or diagnostic tools have become the must in the pharmaceutical industry, in medical biotech and in the research world. 

Purification of this type of biosimilar requires a particular know-how. In this Guide, you'll discover how purification methods already validated in GMP industrial processes, are now brought to R&D scientists.

Download your Guide and see how it's possible!

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