SUPPLYING DISCOVERY TOOLS

FEBRUARY 2016

NEWS HIGHLIGHT

Wnt pathway: new promising therapeutical candidates

The Wnt cell signalling pathway is a high-potential therapeutical target in cancer research. It’s deeply linked to cellular fate through modulating cell proliferation, mobility, interaction, and polarity. Wnt is not only a key player in the embryonic development but also in the homeostasis, and remodeling of adult tissues (heart, bone, neural tube, angiogenesis…) via somatic stem cell modulations and stem cell self-renewal. Abnormal Wnt signaling events are seen in various types of human carcinomas and in a variety of other cancer types.

Download your Guide to the best tools for analysing this pathway

Solute Carrier Transporter studies made easy

Solute carrier (SLC) transporters play a role in the up-take of various drugs, as well as endogenous nutrients into cells and thus may influence the ADME properties of, or indeed adverse reactions to, a compound of interest. Investigation of SLC transporters is expected to be helpful during drug development.

Now, you can easily access SLC research tools, licenced with the patent covering your use of the cell lines including publication. GenoMembrane's TRANSiPort product line is now available across Europe through tebu-bio.

Discover ready-to-use cellular models for your SLC assays

PRODUCT FOCUS

One year on: Live Cell Imaging with SiR-actin, SiR-tubulin & SiR-DNA

Launched just over a year ago, SiR-Actin and SiR-Tubulin have been available on the market providing the most convenient tools to stain F-actin and Microtubules in living cells. In the meantime, Spirochrome have launched a third stain based on the SiR-technology – SiR-DNA to stain DNA in living cells....

Which results have other researchers obtained with these stains?

Screen for inhibitors of PD-1 signaling

Therapeutic manipulation of immunopathways has led to promising clinical results for the treatment of a number of diseases, with the first therapeutic antibodies now brought to the market and approved for treatment of diverse cancer types.

In this post, our specialist reviews a versatile tool to screen for activators or inhibitors of PD-1 signaling, or characterize biological activity of PD-1, and its interaction with ligands.

Run cell based inhibitor screenings on PD-1/PD-L1/PD-L2 binding

PROMOTIONS

Pure and scalable protease inhibitors... with a discount!

Regardless of the application, Life scientists are looking for pure and scalable protease inhibitors. Protease inhibitors have a dual use in lab research. They can be used as stand-alone inhibitors to prevent degradation of protein of interest during purification or cell/tissue extractions.

Get 10% discount off your protease inhibitors

NEWS

Ubiquitin ligase assay kits - now flexible

A ready-to-use E3 ligase activity enzymatic assay, the E3LITE kit, has been recently released enabling researchers to screen for E3 enzyme inhibitors and potentially new therapeutical drugs. What’'s it for and why is it of interest? [ Read more ]

New findings in the TGF-beta pathway

Three papers on the role of the TGF-beta pathway in different cancers have recently been published. It was already known that this pathway is involved in processes such as cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The pathway as such works in quite a simple way... 
[ Read more... ]

 TECHNICAL CORNER

Antibody-based techniques are widely used in Life Science laboratories. Antibody purification is often required to raise purity yield of antibody production batches or to reach publication-grade data. In this post, Ana gives you some useful technical tips and troubleshooting points to optimize your experimental conditions. 

Improve your antibody purification

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