DRUG DISCOVERY

May 2014  

News Highlight

What makes EZH2 a valuable druggable target?

Multiple lines of evidence make EZH2 a valuable target for drug discovery studies due to its implication in epigenetics, as well as interaction with intracellular protein partners (including histones):

  • Abnormal EZH2 expression in various types of cancer (breast, prostate, endometrial cancers…)
  • EZH2 mutations (Tyr641, Ala677 or Ala687) associated
    with non-Hodgkins lymphomas and leukemias
  • EZH2 gene alterations leading to reduced methylation activity (Tyr153 deletion, His689 and Pro132 mutations)...

Discover our full range of active...

Methyltransferases
Demethylases
Mutant or wild-type: 7 effective means to screen and profile Human EZH2 Methyltransferase

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Current News

PARP inhibitors are less synthetically lethal in hypoxic conditions

In recent work presented by tebu-bio during the “Experimental and Molecular Therapeutics” poster sessions at the AACR 2014, Claudine Kiéda’s and Nadia Normand’s teams demonstrated that PARP inhibitors are less synthetically lethal in hypoxic conditions with increased IC50 and survival percentage at higher concentrations.

Read more....

For Human Stem Cell & CNS research:
XCell Science

Introducing a collection of isogenic knock-out iPSC lines mimicking genetic defects identified in CNS disorders, such as Parkinson’s and Alzheimer’s diseases, autism, schizophrenia and amyotrophic lateral sclerosis.
Soon available from tebu-bio, don't wait to learn more about these high-quality neural cell derivatives for your R&D and drug discovery approaches...

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Technical Corner

From the Biomolecules experts...

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