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NOVEMBER 2015

NEWS HIGHLIGHT

Neuromuscular diseases: A new application for Statins?

Statins, HMG-CoA reductase inhibitors are medications to treat Hypercholesterolemia and cardiovascular diseases. Recently researchers suggested that Simvastin might be a valuable therapeutic candidate in neuromuscular diseases.....

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CRISPR/Cas9 vector delivery maximized with DNA-In®

CRISPR-Cas9 is a popular method that brings researchers endless experimental strategies to create their own research-based cellular models. In this post we’ll review a new transfection reagent especially engineered to maximize Cas9 vectors deliveries inside cells with low cellular toxicity.

Discover DNA-In® CRISPR transfection reagent

PRODUCT FOCUS

Fluorescent thermometer for living cells

Thousands of researchers spend time pampering their primary cells and cell lines every day, with the aim of defining their optimal cell culture conditions. Researchers are in effect trying to control numerous cellular parameters (oxygene levels, fresh media supply, incubation temperature…) and monitor their “viability” on a regular basis. But what about the internal cellular temperature? Have you ever considered this biological parameter to monitor the “wellness” of your cultivated cells? In this post, let’s take a look at the characteristics of a new, cell permeable, fluorescent thermometer for living cells.

Take a look at the characteristics of a new thermometer for living cells

A new fast and sensitive PGE2 Immunoassay kit

PGE2 is a potent lipid mediator involved in maintaining homeostasis but also in the promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Recently, researchers have shown that the activation of the NLRP3 inflammasome in human primary monocyte-derived macrophages is inhibited by PGE2 confirming the role of this lipid is an effective autocrine and paracrine inflammatory modulator maintaining homeostasis during the resolution phase of inflammation. This paper also proves the importance of having access to simple but robust PGE2 quatitative assays.

Which Prostaglandin E2 Immunoassay kit to choose?

NEWS

Cancer and immune cells crosstalk: immunoediting

Immunoediting of cytokine signals provides another area of pathways which tumours utilise to evade and potentially escape from immunological targeting. This post aims to shed some light into the Tumour Microenvironment (TME) and particularly on how the tumour recruits accomplices to grow and disseminate...
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Win 400€ towards your next scientific meeting

As an expression of our commitment towards developing European life sciences, our Researchers Travel Grant program was started in 2006 to help European life scientists meet their expenses towards attending a life sciences meeting of their choice, anywhere in the world.

Dates are now announced for the 4 draws in 2016 -  with 6 winners for every draw who will each receive 400€! [ Read more... ]

TECHNICAL CORNER

Collagen, Elastin, and Proteoglycans are major components of the Extracellular Matrix where they form highly complex networks. ECM builds up an environment which  supports  surrounding cells and plays a crucial role in cell-to-cell communication, cell adhesion, and differentiation.

The monitoring of ECM components during experimental approaches requires robust and user-friendly in vitro assays. In the past experimental methods (e.g. soluble collagen measurement) were laborious and based on the use of harmful chemicals. Today, easy-to-use and straightforward methods with colorimetric read-outs are routinely used.

7 easy colorimetric assays to measure ECM components

Because of their rapid growth and their affordability, bacterial expression systems are very convenient when producing recombinant proteins. Nevertheless, one of the key elements in the design of the experimental procedures for producing a recombinant protein in E. Coli is the selection of the right bacterial strain for the right protein. This is not an easy step but remains of most importance.

Based on our in-house experience, we’ve compiled a guide aimed at helping you in your choice of the “ideal” engineered bacterial strain for efficient recombinant proteins expression.

Learn more and download your copy of the guide

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