Gene Expression
and Molecular Biology

OCTOBER 2015

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NEWS HIGHLIGHT

RNA Therapy and the Innate Immune Response

The idea to use RNA oligos as a therapeutic has been around since the late 1990s, however there is now an explosion of renewed interest. The Wall Street Journal‘s exclusive billion dollar club includes the RNA therapy companies Moderna and CureVac along side the likes of Uber and Airbnb. 

Using RNA molecules directly as a therapy rather than delivering DNA or protein into a cell has many potential advantages.

Learn more about the the rebirth of RNA Therapy

PRODUCT FOCUS

PseudoU-RNA Molecular Weight Markers

Standard RNA ladders such as the DynaMarker® for large or small RNA or double-stranded size determination are routinely used by researchers wishing to confirm the molecular weight of an in vitro transcribed or chemically-synthesized RNA. Due to the altered gel mobility of pseudouridine-containing RNAs, a PseudoU-RNA Molecular Weight Marker can be used to more accurately assess the molecular weight of these modified RNAs.

Discover them

PROMOTION

RedView is a sensitive and stable fluorescent nucleic acid stain designed to replace the highly toxic ethidium bromide (EtBr) for detection of dsDNA, ssDNA or RNA in agarose and polyacrylamide gels.

 

Try RedView DNA Gel Stain with 10% discount

TECHNICAL CORNER

Recently, an article demonstrated that small RNAs can possess a large variety of 5' cap structures including a 2,7 dimethylguanosine modification and found multiple cap structures (mGpppC, 7mGpppG, GpppG, GpppA, and 7mGpppA) in small RNA pools. This adds a further level of complication to small RNA sequencing library prep, as such protocols generally allow for sequencing only of RNAs with a 5' monophosphate.

Discover top products & services for your small RNAs studies

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