Drug Discovery
Ion Channels Focus

SEPTEMBER 2015

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NEWS HIGHLIGHT

Ion channel Focus – over expressing cell lines for inhibitory screening

Ion channels are proteins with pore-forming abilities. Their selective capabilities to let ions cross the cell membrane involves them in crucial cellular functions (controlling membrane potential, the flow of ions, regulating cell volume).
As ion channels are involved in the patho-physiology of so many diseases, they are natural candidates for pharma R&D programs.

To screen for ion channel inhibitors, cell lines are needed to expose functional ion channels to potential drug candidates. These cells lines have to stably express the ion channel of interest and should be characterized in terms of functionality of the respective channel.

Take a look at cell lines over expressing specific ion channels

High resolution structure of the TRPA1 channel protein

One of the hottest news last month was the high resolution structure of the TRPA1 ion channel protein.TRPA1 is a sensor for environmental noxious agents or signaling molecules produced endogenously. 

The structure was solved in the presence of agonist and antagonist ligands by using single-particle electron cryo-microscopy.

Learn more here

PRODUCT FOCUS

Venomous toxin ion channel modulators

Ion channels are proteins with pore-forming abilities. Their selective capabilities to let ions cross the cell membrane involves them in crucial cellular functions (controlling membrance potential, the flow of ions, regulating cell volume). Ion channels are involved in the patho-physiology of so many diseases, they are natural candidates for pharma R&D programs. Here, we review a series of highly selective ion channel modulators which are ideal for performing drug discovery screenings....

Discover our toxin ion channel modulators

NEWS

 

State-of-the-art Calcium measurement with Fluo-8

G Protein Coupled Receptors (GPCR) and ion channels are important targets in drug development. Both target classes represent membrane proteins which require convenient and robust cell based assays for screening campaigns. In GPCR cell based screenings, intracellular Calcium concentration is usually used as readout. The same is true for calcium ion channel screenings. Thus Ca2+ indicators are needed which meet the demanding expectations of researchers engaged in assay development and screenings.... [ Read more ]

How to modulate ion channels?

Ion channels play an important role in perception and transmission of pain sensations. Furthermore, dysfunctions of certain ion channels are involved in neuronal disorders, such as epilepsy, Alzheimer’s disease, Parkinson’s disease, schizophrenia, and many others. Mutations in ion channel genes have been linked to a wide varity of diseases like policystic kidney disease, cystic fibrosis, and total colour-blindness, to mention just a few. This makes ion channels natural candidates for pharma R&D programs.
In this post, we invite you to take a look at molecules which specifically block or activate ion channels of different classes. [ Read more ]

MEET US

tebu-bio's experts will be present at:

We are happy to sponsor "Seeing is Believing - Imaging the Processes of Life", a symposium which will place in Heidelberg from October 6th to 10th.

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