Drug Discovery
Apoptosis & Caspases


May 2015

News

Caspases as pharmaceutical targets – screening for inhibitors?

Caspases belong to the family of cysteine proteases and are involved in networks controlling cell death and inflammation. Human Caspases have been classified according to their roles in apoptosis (Caspase-3, -6, -7, -8, and -9) and inflammation (Caspase-1, -4, -5, and -12). Caspase-2, -10, and -14 can be less easily classified concerning the function).

Interest in caspases has been growing since the 1990s, because they are potential therapeutic targets, due to their role in apoptotic processes involved in some diseases like cancers and autoimmune or degenerative diseases ( Alzheimer's disease).

 

Ferroptosis – and the way to inhibit it

Ferroptosis is a recently recognized form of regulated necrosis.This form of cell death could be a possible therapeutic approach to treat tumor cells. Some studies showed that ferroptosis also occurs in non-transformed tissues, implicating this pathway in the development of a wide range of pathological conditions.

 

Product Focus

How to measure early apoptotic events?

Apoptosis is the most prominent process of programmed cell death. It involves a complex cascade of reactions regulated by specific proteases called caspases and results in DNA degradation. Apoptotic processes have been researched in an extensive variety of diseases. Excessive apoptosis causes atrophy, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. Besides apoptosis other types of programed cell death are known, such as autophagy, necroptosis, and ferroptosis.


How to detect active caspase in cells?

In this post, Ali, our specialist gives an overview of a method and kits which allow to detect active Caspases in cells, and which give an insight into the apoptotic status of the respective cells. Investigate the effects of inducers of apoptosis in living cells!


Modulating or inhibiting Caspase activities

In this post, explore Caspase inhibitors/modulators, which allow for in-depth characterisation of your enzyme of interest and which can serve as reference compounds in caspase inhibitor screenings. 

Promotions

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Technical Corner

How to differentiate between Apoptosis, Necroptosis, Autophagy & Ferroptosis

"Cell death can be caused by external factors such as infection or trauma – a process which is called necrosis. On the other hand, cell death can be mediated by intracellular programs – in this cases we talk about programmed cell death.
What are the different types of programmed cell death?..." Read more...


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