Gene Expression & Molecular Biology

October 2014

News Highlight

Fast & safe mRNA reprogramming

Early reprogramming methods utilized retroviral (including lentiviral) vectors to introduce reprogramming-associated transcription factors to the target cells. Since then, the focus has been on developing reprogramming technologies that reduce or eliminate the risk of insertional mutagenesis and the biohazards associated with viral vectors.

Today, mRNA-based reprogramming has proven to be the only non-viral, non-integrating method for reliable, safe and efficient generation of clinically relevant human iPS cell lines.

New 3D-gene® miRNA and mRNA expression profiling service

Recently, tebu-bio and Toray reached an agreement for miRNA and mRNA profiling lab services. Already a recognised European service provider in genomics, proteomics and cell-based assays, tebu-bio now brings researchers across Europe access to Toray's 3D-Gene® microRNA and mRNA technology profiling services.

Product Focus

Two means to boost RNA Sequencing

RNA-sequencing (RNA-Seq) bottlenecks start with library preparation! Is it possible to prepare a RNA-Seq library in a simple and fast way? Choosing the most convenient and fastest library preparation kit is already a challenge in itself, even before performing RNA-Seq...

The empirical approach to rRNA depletion for NGS

Ribosomal RNA (rRNA) depletion is a must for Next Generation Sequencing (NGS) studies to reduce the number of irrelevant reads. While Ribo-zero is the recognized gold standard for rRNA depletion, there are some experimental situations in which another approach is required. Read more...

Promotions

GeneCopoeia discounts!

Get 20% off a broad selection of vectors, clones, miRNA antagomirs... or even 30% discount off Genome-CRISP™ & Genome-TALER™ kits...

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Current News

EndoG & ATM cell cycle checkpoint

In a recent publication, Gole B. and Baumann C. demonstrate the role of the apoptotic nuclease EndoG in Mixed-Lineage Leukemia breakpoint cluster region (MLLbcr) destabilisation leading to MLL gene rearrangements & leukemogenesis. Read more...

Synthetically lethal ATM or DNA-PKcs inhibitors

Albarakati et al. demonstrate in this recent paper, that BRCA1-BER deficient cells can be the target of a synthetic lethality approach by using ATM or DNA-PKcs inhibitors. Read more...

Technical Corner

Solutions for Genome Editing:
TALEN, CRISPR & Safe Harbor Integration

In this webinar, Ed Davis, Ph.D (Senior Application Scientist) will discuss the advantages and disadvantages of each system, and provide information on GeneCopoeia's powerful suite of genome editing products and services.

Sign up today to learn all about the best Genome Editing tools


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