Biomarker Discovery

April 2014  

News Highlight

Explore the Notch signaling pathway

The Notch signaling pathway plays a vital role in the regulation of asymmetric cell division, cell fate specification and proliferation. Mammals possess 4 different Notch receptors, referred to as Notch1, 2, 3, and 4. The Notch receptor is a hetero-oligomer transmembrane protein that comprises a large extracellular domain, a single-pass transmembrane span, and a small intracellular region.

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Phosphorylation ELISAs - Monitor markers of important signaling pathways in cell lysates

Rapid, convenient and sensitive assay kits to monitor activation or function of important biological pathways
in cell lysates. Screen numerous different cell lysates, without performing Western blot analysis.
  • More sensitive than Western blot (up to 10 times)
  • Complete kit with pre-coated 96 well plate
  • 2 versions of each ELISA kit:
    • phospho-protein alone
    • phospho- and total protein in the samples

Product Focus

Get the best for intracellular staining in FCM!

Intracellular staining of protein biomarkers using antibodies in flow cytometry has opened up a diversity of new options for phenotypic and functional characterisation of cells in both research and clinical diagnosis.

Fix&Perm® is a simple procedure (only 2 reagents), fast (less than one 1 hour), yet ensures consistent, reliable results.


Measure phosphorylation status changes at specific sites in key Cancer Signaling pathways

This phospho Antibody array comes with 269 highly specific and well-characterized cancer signaling antibodies (six replicates) for reliable and consistent biomarker analysis against 95 targets such as:

  • 14-3-3 zeta, AKT, Bad, bcl-2, bcl-xl, BRAC1, caspases, ChK1 and 2, c-jun, c-kit, eEF2K, EGFR, ERKs, FAK, GSK3s, FGFR1, HSP27, Histones, JAK2, MEKs, mTOR, MAPKs, Myc, NFkB, PTEN, Rac, STATs, Tau, VEGFR…
  • From cells, frozen or FFPE tissues, or serum samples

Current News

Exogenous tissue Plasminogen Activator administration increases Hippocampal mature BDNF Levels by Rodier M. et al.

Recent publication where the authors chose discovery tools from tebu-bio to measure Plasmin and t-PA activities with Fluorescent Activity Assays (SensoLyte Rh 110 Plasmin and SensoLyte AMC t-PA respectively).

› Read more...


4 top antibodies for DNA & Histone modifications

High quality, validated antibodies for a variety of applications:
ICC, IF, IHC (P), ChIP, WB, ELISA. Satisfied or refunded

Promotions

Measure Hyaluronic acid by ELISA from as little as 25 ng/ml

The Hyaluronan Sandwich ELISA by Echelon Biosciences, is a quantitative immunoassay designed for in vitro measurement of HA levels in cell culture supernatant, or human/animal biological fluids, requiring only small amounts of sample.

House Phosphorylated: Activate, Signal, Modify

Choose from a broad and varied range of phospho-specific antibodies, to detect your phosphorylated targets with optimal precision.
  • For use in WB, flow cytometry, IHC and IF microscopy
  • Highly accurate & reliable

Technical Corner

Jean-François advises using PBMCs in your immune cell studies

The availability of human peripheral blood mononuclear cells (PBMC) from healthy individuals and from patients with various diseases allows many studies on normal and abnormal functions of human immune cells. Because human and murine immune biology differs in many ways, it is important that various methodologies for studying human immunology are established. The two reports highlighted in this article demonstrate the usage of human PBMCs for mechanistic and pre-clinical human immune cell studies. › Read more...


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