Cell Biology and Signalling

JULY 2016

Live Cell Imaging Focus

Visualizing fixed cells and tissues only gives snap shots of cellular processes.

Gain better insight into dynamic processes in cells and interaction between cellular components, be it proteins or even organelles, with the more and more powerful microscopic tools developed now available to image living cells.

 Access all the best tools here.

Live Cell Imaging Tools at tebu-bio.com

NEWS HIGHLIGHT

Differentiate ES/iPS from differentiated cells

In many experimental setups, it would be preferable to be able to differentiate human ES and iPS cells from differentiated cells. tebu-bio is pleased to announce their cooperation with Goryo Chemical, who specialize in probes for Live Cell Imaging. Goryo Chemical recently launched the Kyoto probe 1 (KP-1), which exactly fulfills this need.

Learn more about this essential product for your research

PRODUCT FOCUS

Live cell imaging of Actin, Tubulin & DNA – SLAS conference

In this post, Ali, our specialist for Live Cell Imaging, introduces the poster presented during the SLAS – High Content Screening Conference, which took place in Dresden/Germany at the end of June This document, written in collaboration with Spirochrome, relates  the features of SiR-stains, which are excellent tools for phenotypic screening and high content screening (HCS) approaches.
 
Download your copy of the poster here

The art of looking at biological processes in real time

Besides elucidating intimate interactions of various cellular components (e.g. Actin, Tubulin and DNA), molecular probes used in live cell imaging allow to accurately monitor biological changes of various parameters in living cells (such as ion concentration variations or any other changes in the cytosol).  tebu-bio’s specialists are constantly searching for innovative and biologically relevant probes for live cell imaging applications.

Discover a selection of the new fluorescent probes

NEWS

Where can you find a new fluorescent probe for super-resolution imaging?

Super-resolution imaging techniques operate beyond the limit set by the diffraction of light, leading to new insights in cellular biology. Among these techniques, the direct stochastic optical reconstruction microscopy (dSTORM) approach is based on the use of blinking fluorescent dyes allowing spatial resolution of about 20 nm.

This post focusses on a new type of fluorescent dye compatible with both live-cell imaging and staining of fixed cells adapted to dSTORM. [ Read more ]

PROMOTIONS

50% off HMSiR fluorescent probes

HMSiR (SuperFluor™ series) is a fluorescent probe which performs spontaneous blinking without the need of high-power laser irradiation.
Super resolution imaging can then be run under more physiological conditions without thiols or oxygen scavengers, which were necessary for previous dSTORM observation.

Offer valid up to September 30th, 2016 - full details at tebu-bio.com

Try HMSiR now

TECHNICAL CORNER

Dye based methods to measure Ca2+ are very well established, whereas there are no dyes available for most of the other second messengers in these signalling pathways.
That’'s why Montana Molecular developed genetically encoded fluorescent biosensors for second messengers such as cAMP, DAG, PIP2, and Ca2+.

Have a closer look at GPCR mediated signalling

tebu-bio recently introduced a new search engine for compounds such as activators, inhibitors and reference compounds.

Now, you can search in a huge compound data base containing molecules offered by leading specialist suppliers such as Focus Biomolecules, TargetMol, Bioaustralis among many others who offer a targeted portfolio of compounds along with enzymes, substrates and kits focusing on diverse research fields (Epigenetics, Ubiquitination...).

Access the largest selection of specialized bioactive small molecules

MEET US

Actin in Action: From Molecules to Cellular Functions

Visit our booth and meet our two specialists Christian Gadomsky and Ingrid Kautner at the next symposium organized by the EMBO and EMBL. This meeting will bring together researchers from different communities interested in actin-related processes and is designed to cover actin organization broadly, from the molecular scale to the whole organism.

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