Methylation of Lysine 27 of Histone H3 (H3K27) is a “silencing mark” associated with imprinting and X chromosome activation. JMJD3 is a histone demethylase that demethylates di- and trimethyl-lysine 27 on histone H3. JMJD3 also plays important roles in HOX gene activation, inflammation, and macrophage differentiation.
BPS Bioscience is the first company to provide recombinant JMJD2C (which demethylates H3K9, another key silencing mark), recombinant JMJD3, and the JMJD3 assay kit.