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Peripheral blood mononuclear cells (PBMCs) have been a popular model system that serves as a circulatory mirror of the in vivo physiological and metabolic activity of cells. Among the plethora of available primary cells, PBMCs and its individual subsets have enabled a broad spectrum of applications from in vitro cell-based assays to the monitoring of ex vivo changes before and after treatment. The applications span across basic discovery stages to preclinical and clinical stages, including direct monitoring of immune responses to therapeutic and vaccine strategies.
In a recent article published in Genetic Engineering & Biotechnology News (GEN), the authors present a snapshot of studies conducted at SeraCare Life Sciences on the cryopreservation and characterization of frozen PBMCs and on companion assays for evaluation of cellular function and for support of a number of other preclinical and clinical applications.
Find PBMCs from SeraCare here.
