SilenciX applications

PARP inhibition vs. PARP-1 silencing different outcomes in terms of single-strand break repair and radiation susceptibility
Godon et al., Cell Cycle 2008; in press

Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents
Aressy et al., Nucleic Acids Res. 2008; in press

Role of ATM in the telomere response to the G-quadruplex ligand 360A
Pennarun et al., Nucleic Acids Res. 2008; 36(5):1741-54

Interplay between cernunnos-XLF and NHEJ proteins at DNA ends in the cell
Wu et al., J. Biol. Chem. 2007;282(44):31937-43

Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in humn stable clones.
Biard, Nucleic Acids Res. 2007 June; 35 (11): 3535–3550

Long-term XPC silencing reduces DNA double-strand break repair
Despras et al., Cancer Res 2007 March; 67 (6): 2526–2534

Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing
Biard, Mol Cancer Res 2005; 3 (9): 519-529

Designer of Small Interfering RNA

An accurate and interpretable model for siRNA efficacy prediction
Vert et al., BMC Bioinformatics 2006; 7:520

Comparison of approaches for rational siRNA design leading to a new efficient and transparent method
Matveeva et al., Nucleic Acids Res. 2007; 35(8): 63