MRP2 PREDIVEZ™ Vesicular Transport kit

The PREDIVEZ™Vesicular Transport kit is a simple and powerful tool to investigate drug-transporter interactions. It provides information on any interaction between the ABC transporter and the test drug that would affect the transport of the fluorescent reporter substrate.

SOLVO's PREDIVEZ™ Kit is available in 3-, 6- and 9-compound sizes for MRP2, MRP3 & MRP5.

The Fluorescent PREDIVEZ™ Kit delivers major advantages over the conventional radioactive Vesicular Transport assay.

• Low inter-assay variability
• Z' factor for MRP2 is ~ 0.74
• Increased automated system compatibility
  
• Larger dynamic range / signal-to-background ratio compared to the radioactive Vesicular transport assay

Data can be presented in transport values (with the help of the calibration curve, included), or in percentages (see Figures below).
3 compounds in 8 concentrations can be screened using one 3-compound Kit.

All reagents to perform the assay are included:

Assay protocol Excel data evaluation sheet MSDSs Reference curves with known interactors