The cyclic nucleotide phosphodiesterases (PDE) comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules. Also, they constitute an important drug target familily. PDE inhibitors have been identified as new potential therapeutics in areas such as pulmonary arterial hypertension, coronary heart disease, dementia, depression and schizophrenia. Sildenafil (Viagra®) is an inhibitor of cGMP specific phosphodiesterase type 5, which enhances the vasodilatory effects of cGMP in the corpus cavernosum and is used to treat erectile dysfunction.

Conscious of the importance of this target family, we have organized on this page the tools which would be usefull to screens for new PDEs inhibitors.