Phosphopeptides are important for investigating the influence of phosphorylation on the structures of peptides and proteins and in understanding the regulatory process mediated by protein kinases. Utilizing optimized Fmoc and Boc methodologies, Anaspec have successfully synthesized numerous serine-, threonine-, and tyrosine-phosphopeptides. For mono-, di-, tri- or multiple phosphoamino acids sequence, selective phosphorylation can be achieved by orthogonal protection strategy or by using Fmoc-protected phosphorylated amino acids produced in-house.



New! Nonhydrolyzable and phosphatase-resistant phosphonate analogs are useful in situations where a researcher does not want the phosphate moiety in a phosphopeptide to be hydrolyzed by the action of phosphatases. The use of 2-amino-4,4-difluoro-4-phosphnobutanoic acid (F2Pab), a pSer mimetic, has served as a nonhydrolyzable pSer analogue for synthesizing specific phosphoserine peptides. F2Pab-derivatized peptides have also been used to develop phosphorylation site-specific antibodies1. With tebu-bio you have the added option of ordering high quality non-hydrolyzable phosphoserine-containing peptides.


We offer the most comprehensive phosphopeptide collection, and the possibility to synthetize custom peptides according to your request (contact Nathalie BERVAS, Brand Manager (nathalie.bervas@tebu-bio.com))