• Permeability assessment - Determine permeability on Caco-2 and bovine blood brain barrier models
• P-gp efflux transporter - In vitro evaluation of P-gp (MDR1) substrates & inhibitors (bi-directional transport, uptake/efflux, ATPase)
• Enzyme Inhibition - predicts the potential for compounds to inhibit the metabolism of other drugs and hence risk adverse reactions
• Reaction Phenotyping (enzyme mapping) - used to determine the metabolic pathways involved in biotransformation of compounds
• Species Comparisons - identify the non-human species whose metabolic profile for specific compounds most closely resembles that of man
• Metabolic Stability (turnover) - measure the rate at which compounds are metabolized
• Metabolite Characterization / Identification - determine human-specific metabolites and possible risk of metabolite toxicity
• Hepatotoxicity - measure the result of exposure to a potential toxicant (primary or immortalized hepatocytes)
• Enzyme Induction (in-vitro and ex-vivo) - assess the potential for candidate compounds to up-regulate genes, increase the production of mRNA or protein, or induce enzymatic activity in comparison to each other and to known compounds.
• PrediScreen Service Solutions - Determine drug-transporter interactions. Efflux and uptake transporters.

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