Nuclear factor kappaB (NF-kB) is a major transcription factor that plays an essential role in several aspects of human health. Its dysregulation is associated with inflammation and many severe disease states such as AIDS, atherosclerosis, cancer.

A wide range of tools is available to study NF-κB signaling pathways.

• NF-kB transcription factor assays allow to measure the DNA binding activity in ELISA-based format.
• A new NF-kB inhibitor, QNZ displays potent inhibitory effects on both NF-kB transcriptional activation (IC50=11 nM) and TNFa production (IC50=7 nM).
• The Oligo GEArray^® NFκB Signalling Pathway Array (Cat nr OHS-025) profiles the expression of 113 genes related to NFκB-mediated signal transduction. The same pathway can be analysed by real time PCR by using NFkB Signalling Pathway PCR Array (Cat nr APH-025).
• Several ready-to-use siRNA or plasmid based shRNA are also available in our online catalogue to silence NFkB gene.
• We also offer many specific antibodies against NFkB subunits.

To find the products related to the IkB protein family and IkB kinase family please use our search engine with the name of the protein you are interested in.