The SureSilencing™ Pre-Designed shRNA Plasmids specifically knock down the expression of every human, mouse or rat gene by RNA interference (SuperArray Biosciences, MD). For each gene, we provide four plasmids each with a different pre-designed short hairpin RNA (shRNA) sequence.

Two different plasmid formats for the SureSilencing™ shRNA are available.

• Plasmids containing the neomycin resistance gene let you select for stably transfected cells and study long-term effects of gene knock-down in your cells.
• Plasmids containing the GFP gene offer a better alternative to siRNA letting you identify and track transiently transfected cells and study short-term effects in a transient transfection.

Unlike chemically synthesized siRNA, plasmid-based shRNA provides a renewable source of RNA interference. You can amplify enough plasmid in your own lab to complete your project. Purchase of our plasmids also includes complete shRNA sequence information.

Search for pre-designed plasmids containing shRNA for your human, mouse, or rat gene of interest with our search engine by the name of your target.