Heat shock proteins perform a wide variety of cellular functions such as protein folding, assembly, traffiking, regulation, etc. This page will give you an overview of our offer by category of products on these exciting proteins.

Exciting products related to Hsp90
Emerging evidence indicates that Hsp90 represents a candidate drug target based on the plethora of key signaling molecules that the 90-chaperone is known to regulate or stabilize as well as the differences in the expression and activity profiles in diseased versus normal tissues.

- Hsp90 alpha ELISA kit a highly sensitive sandwich immunoassay designed to measure levels of Hsp90alpha protein in cell lysates, tissue extracts and serum.

- Geldanamycin It binds specifically to HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases. It induces the inactivation, destabilization and eventual degradation of HIF-1α.

- 17-AAG a less toxic and more stable analog of geldanamycin. It induces the inactivation, destabilization and eventual degradation of HIF-1α4.

- 17-DMAG (17-Dimethyaminoethylamino-demethoxygeldanamycin) a less toxic and more stable analog of geldanamcyin with superior pharmacological properties.

- 17-GMB-APA-GA An analog suitable for preparation of geldanamycin immunoconjugates7-9.

Please inquire about the following geldanamycin analogs:
Biotin-Geldanamycin A useful analog for affinity purification of HSP90 and related proteins containing ATP-binding domains6
Aminopropylaminogeldanamycin A novel analog containing a linker arm that can accommodate various coupling chemistries
17-DMAPG 17-Dimethylaminopropylaminogeldanamycin A new analog with moderate potency at inhibition of SKBr3 tumor cells.