These unique Hypothalamic cell lines, provide researchers with a continuous source of cells for use in the discovery and development of new therapeutics targeted to diseases and disorders such as obesity, stress and metabolic disorders.

These hypothalamic cell lines are easy to culture (requiring only standard media formulations), efficiently transfected, and have robust gene and protein expression

• New technology to generate brain immortalized cell lines
• Immortalized from mouse hypothalamic primary cultures
• 38 unique clonal mouse cell lines expressing specific neuropeptides
• Each cell line being fully characterised (>70 Biomarkers analysed).

The characterisation table is a convenient system to choose the most suited cell lines.

Some of our more popular markers include:

Peptides Neuropeptide Y (NPY) Pro-opiomelanocortin (POMC) Corticotropin Releasing Hormone (CRF) Galanin Agouti-related Peptide (AgRP) Proglucagon Growth Hormone Releasing Hormone (GHRH) Urocortin Orexin Melanocortin-concentrating Hormone (MCH) Oxytocin Ghrelin Neurotensin (NT) Arginine vasopressin

Receptors Estrogen Receptor alpha Estrogen Receptor beta Androgen Receptor (AR) Glucagon-like Peptide 1 (Glp1-R) Glucagon-like Peptide 2 (Glp2-R) Leptin Growth Hormone Secretagogue (GHS-R/Ghrelin-R) Neurotensin (NTR-1) Melanocortin (MC4R) Progesterone (PR) Insulin R Melanin-concentrating Hormone (MCH R1) Neuropeptide Y 1,2,4,5 (NPY) Adiponectin R1 & R2

Enzymes Tyrosine hydroxylase Tryptophan hydroxylase Aromatase Glucokinase Choline acetyltransferase Glutamic acid decarboxylase (GAD 67)