Animal Primary Cells
Canine Chondrocytes (CnC)

 
Canine Chondrocytes (CnC) are isolated from normal canine articular cartilage. They are cryopreserved at first passage and can be cultured and propagated at least 10 population doublings. CnC cultured in agarose 3-D constructs of osteoarthritis (OA) model were used to test the effect of carpofen and dexamethasone1. Porous gene-supplemented collagen-glycosaminoglycan (GSCG) matrices were fabricated to provide sustained release of plasmid DNA carrying therapeutic gene to articular chondrocytes2. Autologous chondrocyte implantation (ACI) in a canine model was evaluated in terms of change in composition of reparative tissue with time3. Cultured autologous chondrocytes were used in treating articular cartilage defects as compared with microfracture, a type-II collagen matrix4.   Animal Cells - Canine Chondrocytes  
Characterization: Positive for smooth muscle specific a-actin expression.
 
Product Name Product Description Size (vol)

Cat. No.
CnC Total Kit

Each kit contains an ampoule of cryopreserved CnC (Cn402-05), 500 ml of Canine Chondrocyte Growth Medium (Cn411-500), and a Subculture Reagent Kit.

 1 Kit 095Cn402K-05
Cryopreserved CnC (>500,000 cells in an ampoule) Cryopreserved at first passage in Canine Chondrocyte Basal Medium that contains 10% FBS and 10% DMSO. 1 Ampoule 095Cn402-05
Canine Chondrocyte Growth Medium

Optimized and ready for use.

 500 ml 095Cn411-500
Canine Chondrocyte Growth Medium Kit Basal Medium & Growth Supplement packaged separately. Yields 500 ml 095Cn411K-500
Canine Chondrocyte Basal Medium Add Growth Supplement before use. 500 ml 095Cn410-500
Canine Chondrocyte Growth Supplement   50 ml 095Cn411-GS
Canine Chondrocyte Differentiation Medium   250 ml 095Cn411D-250
Subculture Reagent Kit 100 ml each of HBSS, Trypsin/EDTA & Trypsin Neutralizing Solution 100 ml 095090-K
 
  1. Dvorak, L.D. et al, Am. J. Vet. Res. 63(10):1363-9 (2002).
  2. Samuel, R.E. et al, Hum. Gene Ther. 13(7):791-802 (2002).
  3. Breinan, H.A. et al, J. Orthop. Res. 19(3):482-92 (2001).
  4. Breinan, H.A. et al, J. Ortho. Res. 18(5):781-9 (2000).
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