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Bovine large artery endothelial cells are derived from the arteries of USDA-inspected cattle. They are cryopreserved at second passage (BCAEC at third passage) and can be cultured and propagated at least 16 population doublings. These cells play critical roles in cardiac homeostasis. Changes in structure and function of endothelial cells have been linked to vascular diseases such as thrombosis1,2, atherosclerosis3, and hypertension4. They are an economical alternative suitable for the studies of endothelial function and endothelial metabolism. A more sophisticated cell culture system, closer to the in vitro interactions of endothelia and smooth muscle cells, is generated by co-culture with species-matched bovine arterial smooth muscle cells.
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Characterization: Positive for DiI-Ac-LDL uptake.
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