| description | The benzothiazole dye thioflavin T (ThT) is a classic amyloid stain for senile plaques containing Beta-Amyloid4 peptide in Alzheimer's disease brain. ThT also binds rapidly and specifically to the anti-parallel Beta-sheet fibrils formed from synthetic B-amyloid (1-40), but does not bind to monomer or oligomeric intermediates.
ThT is a useful probe for the aggregated fibrillar state of B-amyloid (1-40) fibrils as the amyloid-specific fluorescence reports only fibrillar species. The binding of ThT does not interfere with the aggregation of this peptide into amyloid fibrils. |
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