| description | 98%, MW=379.5 [26993-30-6] Storage: -20°C
Sphingosine-1-phosphate is a putative second messenger that mobilizes calcium from intracellular stores via an IP3 independent pathway1. This pathway is involved in IgE receptor (FceRI)-mediated calcium mobilization2. Other demonstrated effects include suppression of ceramide-mediated apoptosis3, activation of the MAP kinase4, activation of phospholipase D5, inhibition of chemotactic motility and invasiveness of tumor cells6 and stimulation of quiescent Swiss 3T3 fibroblast growth7. Ligand for S1P1 (EDG-1), S1P2 (EDG-5), S1P3 (EDG-3), S1P4 (EDG-6) and S1P5 (EDG-8) receptors8. |
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