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The Rat MRP2 assay kit operates with fluorescent 5(6)-Carboxy-2',7'-dichlorofluorescein (CDCF) probe (reporter) substrate. A representation of the assay is shown in Figure 1.

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Figure 1. Effect of drugs on rat Mrp2 mediated CDCF transport measured in the vesicular transport assay.

The PREDIVEZ^™ Vesicular Transport kit is a simple and powerful tool to investigate drug transporter interactions. It provides information on any interaction between the ABC transporter and the drug candidate that would affect the transport of the fluorescent or radiolabeled probe substrate.

The PREDIVEZ^™ vesicular transport kits are available in three sizes 3, 6 and 9 compound sizes. Kits contain sufficient amount of reagents and membrane preparation for testing 3, compounds per 96-well plate. Each kit is accompanied by a CD that includes the assay protocol, Excel spreadsheet with data processing template, MSDS and inhibition curves with reference compounds.

Related products

Human ABC transporters	Rat ABC transporters
SB-MDR1-PREDIVEZ-VT	SB-rat-MDR1-PREDIVEZ-Sf9-VT
SB-MRP5-PREDIVEZ-Sf9-VT
SB-MRP3-PREDIVEZ-Sf9-VT
SB-MRP2-PREDIVEZ-Sf9-VT

Human ABC transporters

BSEP

BCRP

MDR1

MRP1

MRP2

MRP3

MRP5