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06 Jun
Assays for analyzing pathway signaling activity

Cignal™ Reporter Assay System (SuperArray Biosciences) are valuable cell-based tools for assessing the biological impact of RNA interference, protein overexpression or small molecule drug treatment. Cignal™ Reporter Assays enable you to rapidly identify which cell signaling pathways contribute to the function of your favorite genes or chemical compounds.

Versatile System

Cignal™ Reporter Assays quantitate pathway-specific transcription factor activation using either dual-luciferase or green fluorescent protein (GFP) detection platforms.

Cignal™ Reporter Single Pathway or 10-pathway assays

The Cignal™ Reporters are available as single pathway assays or as 10-pathway suites, allowing you to monitor an individual pathway or obtain a comprehensive view of multiple pathways involved in a biological process.

Cignal™ 10 Pathway Reporter Assay Suites

Application Product Name Cat. #
Cancer Cignal Cancer Reporter Assay 10-Pathway Suite (luc) CCA-001L
Immunology Cignal Immune Response Reporter Assay 10-Pathway Suite (luc) CCA-002L
Development and Cell Cycle Cignal Growth & Differentiation Reporter Assay 10-Pathway Suite (luc) CCA-003L
Pharmacology/Toxicology Cignal Stress & Toxicity Reporter Assay 10-Pathway Suite (luc) CCA-004L

 

Cignal™ Reporter Single Pathway

Pathway Transcription Factor Dual-luciferase
Catalog #		 MGFP
Catalog #
C/EBP C/EBP CCS-001L  
cAMP/PKA CREB CCS-002L CCS-002G
Cell Cycle E2F/DP1 CCS-003L  
p53/DNA Damage p53 CCS-004L  
Estrogen Receptor Estrogen Receptor (ER) CCS-005L  
Glucocorticoid Receptor Glucocorticoid Receptor (GR) CCS-006L  
Hypoxia Hypoxia-inducible factor-1 (HIF-1) CCS-007L  
Type I Interferon STAT1/STAT2 CCS-008L  
Interferon Gamma STAT1/STAT1 CCS-009L  
MAPK/ERK Elk-1/SRF CCS-010L CCS-010G
MAPK/JNK AP-1 CCS-011L CCS-011G
c-myc Myc/Max CCS-012L  
NFκB NFκB CCS-013L CCS-013G
Notch RBP-Jk CCS-014L  
PKC/Ca++ NFAT CCS-015L  
Retinoic Acid Receptor Retinoic Acid Receptor (RAR) CCS-016L  
TGFβ SMAD2/SMAD3/SMAD4 CCS-017L CCS-017G
Wnt TCF/LEF CCS-018L CCS-018G

 

 

 

Exceptional performance

Every reporter assay is individually engineered to exhibit outstanding sensitivity, specificity, and signal-to-noise ratio.

 

Feel free to contact our product specialist for further information: Aurélie SERRA, PhD

 

 

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