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2vials EUR 1610
1610€


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GAL4 Reporter (Luc)-HEK293 cell Line

Product name
GAL4 Reporter (Luc)-HEK293 cell Line
Catalog number
60655 (2vials)
Description
The Glucocorticoid Receptor Pathway GAL4 Reporter (Luc) - HEK293 Cell Line contains afirefly luciferase gene under the control of glucocorticoid receptor ligand binding domain that isfused to the DNA binding domain (DBD) of GAL4 (GAL4 DBD-GR) stably integrated intoHEK293 cells. This fusion construct activates firefly luciferase expression under the control of amultimerized GAL4 upstream activation sequence (UAS). This allows for specific detection ofglucocorticoid-induced activation of the glucocorticoid receptor without the need for individualtranscriptional targets and with low cross-reactivity for other nuclear receptor pathways. This cellline is validated for response to stimulation of dexamethasone and to the treatment withmifepristone, an inhibitor of the glucocorticoid signaling pathway. 
Product category
Cells, Media & Fractions
Product sub category
Cell Lines
Target species
Human
Format
Cryopreserved
Machine type
Recombinant Cell Lines/Cell Signaling Pathway
Shipment info
Dry Ice
Source
BPS Bioscience

Protocol

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